Kalidou Koulibaly I am happy in Naples

first_imgNapoli in-demand defender Kalidou Koulibaly has dropped a hint over his future amid Barcelona and Manchester United transfer talkEver since his arrival from Genk back in 2014, Koulibaly has imposed himself as one of the key figures in Napoli squad, having accumulated a total of 176 appearances for the Partenopei in all competitions.Known for his physical strength and his dominance in aerial duels, the 27-year-old Senegal international has established himself as one of the most reliable defenders in the Italian Serie A.His impressive performance at the Stadio San Paolo has drawn up the attention of several notable Europe clubs, including Barcelona and Manchester United.In his recent interview with Il Corriere dello Sport, Koulibaly has explained his situation at Napoli, with Calciomercato being the one to transcribe his words.harry maguire, manchester UnitedMaguire says United need to build on today’s win George Patchias – September 14, 2019 Harry Maguire wants his United teammates to build on the victory over Leicester City.During the summer, Harry Maguire was referred to as the ultimate…“My caretaker keeps telling me: ‘You cry twice in Naples, when you arrive and when you leave.’ I always reply: ‘I didn’t cry when I arrived, but I will cry a lot the day that I will leave If I’ll ever leave.”“I am happy in Naples,” Koulibaly said.“Sometimes people speak badly, but they don’t know how it feels to leave here. If you don’t live here, you can’t understand.”Napoli president Aurelio De Laurentiis has recently extended Koulibaly’s contract until 2023 and would hardly accept to sell him unless a stratospheric offer was to arrive at his desk.last_img read more

Tags: , , , , , , , , ,

City audit confirms more employees opting to leave than retire

first_img 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – A report from the City Auditor’s office shows San Diego does a poor job of keeping high performing employees, and is not effective in punishing poor performing employees. These, and other factors are costing taxpayers about 39 million dollars annually. The problems center around recruitment, employee development, and career advancement. 431 managers, supervisors and 40 percent of city workers were surveyed. The report found the number of retirements or other separations intersected in 2016, and now more employees are leaving than retiring. 30% of respondents felt the city was not effective in retaining workers but did a much better job in recruitment and career advancement- but it got low marks for not punishing workers who were performing poorly. KUSI’s Steve Bosh has more: Steve Bosh Categories: Local San Diego News FacebookTwitter Posted: September 11, 2018 September 11, 2018 Steve Bosh, City audit confirms, more employees opting to leave than retirelast_img read more

Tags: , , , , , , , ,

Jon Stewart on New Yorkers Obama Cover Its Just a Fing Cartoon

first_imgCheck out the video: Among the absurd amount of reactionary hype the New Yorker’s controversial Obama cover generated this week, my favorite response comes from the Daily Show’s Jon Stewart, who sums up some of my sentiments nicely.He also criticizes Obama for denouncing the cover:”Really? You know what your response should’ve been? It’s very easy: Barack Obama is in no way upset about the cartoon that depicts him as a Muslim extremist. Because you know who gets upset about cartoons? Muslim extremists! Of which Barack Obama is not. It’s just a f*cking cartoon!”last_img

Tags: , , , , , , , ,

Rodale Hires President

first_imgRodale has hired former Dow Jones executive, Scott Schulman, as its president—a role left vacant since Steven Pleshette Murphy stepped down as president and CEO in 2009.Maria Rodale, who assumed Murphy’s CEO duties at the time of his departure, had stated her intention to hire both a president and COO in July.Schulman [pictured] had been at Dow Jones for 13 years, most recently as president of corporate markets, before leaving in 2012 amidst a slew of executive changes at the company. Schulman was publisher of The Wall Street Journal Online early in his tenure with Dow Jones, returning the group to profitability by introducing new revenue streams and expanding its subscription model. Todd Larsen, now EVP and group president of Time Inc.’s news and sports group, was also part of last year’s executive shakeup at Dow Jones.Maria Rodale is expected to retain an “active” role as CEO, though it will focus on “broader strategic initiatives” within the company, while Schulman will be responsible for strategy and revenue growth. The COO search has been postponed for the time being.”When I took over as CEO four years ago, I had all aspects of the business reporting directly to me,” Rodale says. “The main purpose of [Schulman’s] role is to have all the brands reporting up to him. He’s really going to be running the brands on a day-to-day basis.””We’re at a place where the company is healthy,” she adds. “I’m not as concerned with the day-to-day operating of the brands. I’m more concerned about how we prepare for the future.”Rodale named several potential revenue-drivers the company could pursue moving forward—new content verticals, e-commerce and events were among them—but says they’re just investigating them at this point. A paid content model like the one Schulman helped pioneer at The Wall Street Journal is also in play, she says. Schulman joins Rodale as the company posted a 12-percent year-over-year increase in ad pages across brands in the first half of 2013.Among its larger titles, Men’s Health (up 24.8 percent), Women’s Health (up 26.9 percent) and Runner’s World (up 14.3 percent) each saw significant growth, per PIB. Its smaller magazines, including Runner’s World (up 0.5 percent) and Bicycling (down 1.9 percent) were relatively flat however. Overall, the company says its projecting record ad revenues for 2013.”Rodale has an inspiring mission, compelling content, an impressive customer base, and multiple distribution platforms,” Schulman says in a statement. “I’m thrilled to partner with Maria and the entire Rodale family, as well as its immensely talented brand leaders, to build upon the company’s legacy and its unprecedented success of the past year.” Schulman will officially begin on Oct. 28.last_img read more

Tags: , , , , , , , , ,

Google Chromes Canvas app lets you unleash your artistic ability

first_img Lenovo Smart Clock: $59.99 (save $20) $90 at Daily Steals via Google Express Comments Post a comment Lenovo 130-15AST 15.6-inch laptop: $210 (save $90) Use promo code 19LABOR10 to get an unusually good deal on JBL’s interesting hybrid product — not quite headphones, and not quite a traditional speaker, but something you wear like neckphones to listen to music on the go. Though not technically a Labor Day sale, it’s happening during Labor Day sale season — and it’s too good not to share. Nationwide Distributors, via Google Express, has just about the best AirPods deal we’ve seen (when you apply promo code ZBEDWZ at checkout). This is for the second-gen AirPods with the wireless charging case. Can’t imagine these will last long at this price, so if you’re interested, act fast. HP Laptop 15t Value: $520 (save $780) I thought this might be a mistake, but, no, the weirdly named HP Laptop 15t Value is indeed quite the value at this price. Specs include an Intel Core i7 processor, 12GB of RAM, a 256GB solid-state drive and a 15.6-inch display. However, I strongly recommend paying an extra $50 to upgrade that display to FHD (1,920×1,080), because you’re not likely to be happy with the native 1,366×768 resolution. Read Lenovo Smart Clock review Read DJI Osmo Action preview Internet Services Tech Industry Turo 0 $261 at Daily Steals via Google Express Boost Mobile Read the Rylo camera preview Share your voice JBL Soundgear wearable speaker: $90 (save $160) CNET may get a commission from retail offers. Other Labor Day sales you should check out Best Buy: In addition to some pretty solid MacBook deals that have been running for about a week already, Best Buy is offering up to 40% off major appliances like washers, dryers and stoves. There are also gift cards available with the purchase of select appliances. See it at Best BuyDell: Through Aug. 28, Dell is offering an extra 12% off various laptops, desktops and electronics. And check back starting Aug. 29 for a big batch of Labor Day doorbusters. See it at DellGlassesUSA: Aug. 29 – Sept. 3 only, you can save 65% on all frames with promo code labor65. See it at GlassesUSALenovo: The tech company is offering a large assortment of deals and doorbusters through Labor Day, with the promise of up to 56% off certain items — including, at this writing, the IdeaPad 730S laptop for $700 (save $300).See it at LenovoLensabl: Want to keep the frames you already love and paid for? Lensabl lets you mail them in for new lenses, based on your prescription. From now through Sept. 2 only, you can save 20% on the blue light-blocking lens option with promo code BLOCKBLUE. See it at LensablSears: Between now and Sept. 7, you can save up to 40% on appliances (plus an additional 10% if you shop online), up to 60% on mattresses, up to 50% on Craftsman products and more. The store is also offering some fairly hefty cashback bonuses. See it at SearsNote: This post was published previously and is continuously updated with new information.CNET’s Cheapskate scours the web for great deals on tech products and much more. For the latest deals and updates, follow the Cheapskate on Facebook and Twitter. Questions about the Cheapskate blog? Find the answers on our FAQ page, and find more great buys on the CNET Deals page. $60 at Best Buy Mentioned Above Apple iPhone XS (64GB, space gray) $155 at Google Express Google Nest Hub: $59 (save $70) Chris Monroe/CNET $999 Read the AirPods review Sarah Tew/CNET Formerly known as the Google Home Hub, Google’s Nest Hub packs a wealth of Google Assistant goodness into a 7-inch screen. At $59, this is within a buck of the best price we’ve seen. It lists for $129 and sells elsewhere in the $89-to-$99 range.This is one item of many available as part of eBay’s Labor Day Sale (which, at this writing, doesn’t specifically mention Labor Day, but that’s how it was pitched to us). $59 at eBay Read Google Home Hub review See at Turo DJI’s answer to GoPro’s action cameras is rugged little model that’s shockproof, dustproof and waterproof down to 11 meters. It normally runs $350, but this deal drops it to $261 when you apply promo code 19LABOR10 at checkout. Preview • iPhone XS is the new $1,000 iPhone X $299 at Amazon Sarah Tew/CNET Tidal 3-month family subscription: $5.99 (save $54) See at Amazon Turo: Save $30 on any car rentalcenter_img Sarah Tew/CNET What’s cooler: A snapshot of a firework exploding in front of you, or full 360-degree video of all the fireworks and all the reactions to seeing them? Oooh, ahhh, indeed. At $250, the compact Rylo dual-lens camera is selling for its lowest price yet. And for an extra $50, you can get the bundle that includes the waterproof housing.This deal runs through Sept. 3; it usually costs $500. Angela Lang/CNET $520 at HP Sprint Rylo Amazon Chrome Google,I’m shocked — shocked! — to learn that stores are turning Labor Day into an excuse to sell stuff. Wait — no, I’m not. As much as I respect the original intent of the holiday (which became official back in 1894), to most of us, it’s just a bonus day off — one that’s blissfully tacked onto a weekend. So, yeah, stores; go ahead, run your sales. I’m listening. Perhaps unsurprisingly, Labor Day doesn’t bring out bargains to compete with the likes of Black Friday (which will be here before you know it), but there are definitely some sales worth your time.For example:We’ve rounded up the best Labor Day mattress deals.We’ve also gathered the best Labor Day laptop deals at Best Buy.The 2019 Vizio P Series Quantum is back under $999.Be sure to check out Amazon’s roughly three dozen Labor Day deals on TVs and audio. Google Express is having a big sale as well, one that includes deals on game consoles, AirPods, iPhones, laptops and more.Below I’ve rounded up a handful of individual items I consider to be the cream of the crop, followed by a handy reference guide to other Labor Day sales. Keep in mind, of course, that products may sell out at any time, even if the sale itself is still running. Note that CNET may get a share of revenue from the sale of the products featured on this page. $999 TVs Speakers Mobile Accessories Cameras Laptops Automobiles Smart Speakers & Displays See it Best laptops for college students: We’ve got an affordable laptop for every student. Best live TV streaming services: Ditch your cable company but keep the live channels and DVR. Sarah Tew/CNET Turo is kind of like Uber meets Airbnb: You borrow someone’s car, but you do all the driving. I’ve used it many times and found it a great alternative to traditional car-rental services — in part because you get to choose exactly the vehicle you want (not just, say, “midsize”) and in part because you can often do pickup and dropoff right outside baggage claim.Between now and Sept. 1, the first 300 people to check out can get $30 off any Turo rental with promo code LDW30. We drew a very quick vampire on Google Canvas, but you can probably do better. Google Canvas/Screenshot by CNET Google is letting you doodle within its Chrome browser with a simple app.You can go to Canvas using canvas.apps.chrome and start drawing immediately, as previously reported by Chrome Unboxed.It’s pretty straightforward — you can choose among pencil, ink pen, marker, chalk and eraser, then pick any hex color. This gives you a massive range of palettes.Your drawing is saved to your Google account, and you can download it as a PNG file.Drawing with a mouse or touchpad isn’t ideal (as evidenced by our quick attempt), so would-be Google Canvas artists probably will be better off using a stylus and touchscreen. See It Apple iPhone XS $999 Best Buy The problem with most entry-level laptops: They come with mechanical hard drives. That makes for a mighty slow Windows experience. This Lenovo model features a 128GB solid-state drive, so it should be pretty quick to boot and load software, even with its basic processor. Plus, it has a DVD-burner! That’s not something you see in many modern laptops, especially at this price. DJI Osmo Action camera: $261 (save $89) See It See It $999 An Echo Dot makes a fine match for any Fire edition TV, because you can use the latter to say things like, “Alexa, turn on the TV.” Right now, the 24-inch Insignia Fire TV Edition starts at just $100, while the 32-inch Toshiba Fire TV Editions is on sale for $130. Just add any Fire TV Edition to your cart, then add a third-gen Echo Dot, and presto: The latter is free. $6 at Tidal Rylo 5.8K 360 Video Camera: $250 (save $250) Recently updated to include digital-photo-frame capabilities, the Lenovo Smart Clock brings Google Assistant goodness to your nightstand. It’s a little smaller than the Amazon Echo Show 5, but also a full $30 less (and tied with Prime Day pricing) during this Best Buy Labor Day sale. Free Echo Dot with an Insignia or Toshiba TV (save $50) Review • iPhone XS review, updated: A few luxury upgrades over the XR Apple AirPods with Wireless Charging Case: $155 (save $45) Share your voice 7 Spotify and most other streaming services rely on compressed audio, which robs the listener of full fidelity. Enter Tidal, the only “major” service that delivers lossless audio — meaning at least on par with CD quality, if not better. Want to see (er, hear) the difference for yourself? Grab this excellent extended trial while you can. It’s just $6 for three months, and it’s good for up to six listeners. Tags The Cheapskate Tags $210 at Best Buylast_img read more

Tags: , , , , , , , , ,

Bad loans to Kingfisher Airlines CBI raids on Vijay Mallyas offices residences

first_imgThe Central BUreau of Investigation (CBI) on Saturday raided the houses and offices of Vijay Mallya and his now grounded Kingfisher Airlines in Delhi and Bengaluru in connection with alleged fraud in Rs 900 crore loan given to him by IDBI Bank, a loan that has been declared as non-performing asset.The raids were conducted at five places, officials said.IDBI Bank came under the scanner in 2014 for granting an alleged bad loan to Kingfisher Airlines despite knowing its precarious financial position and negative credit ratings.Mallya’s airline has been grounded since October 2012.A string of Indian banks have an exposure of nearly Rs 7,000 crore in loans to the airline, with the State Bank of India (SBI) leading with Rs 1,600 crore.The Punjab National Bank, Bank of India and the Bank of Baroda have loan exposure of Rs 800 crore, Rs 650 crore and Rs 550 crore respectively.last_img read more

Tags: , , , , , , , , ,

CVC summons WalMart India head in alleged bribery case

first_imgThe Central Vigilance Commission (CVC) has summoned the India head of US-based multinational retail giant Wal-Mart Stores Inc in the wake of allegations that the company had paid massive amounts as bribe in India to obtain regulatory permits for some of its operations.The CVC probe will involve examination of the retailer’s documents and for the first time, the investigation agency is acting on its own based on a media report.”Some observations have been made that Wal-Mart gave some amount to government officials here. It is our duty to look into it,” PTI quoted Vigilance Commissioner TM Bhasin as sayingHe said “the Commission has taken suo motu cognisance of it and summoned country head of Wal-Mart here.””We have asked them to submit details to us by November 15,” Bhasin said.It is also for the first time that the CVC has initiated a probe against a private firm.Wal-Mart is suspected to have paid “thousands of small payments” to junior-level officials in India in order to pass its goods through customs or get real estate approvals, the Wall Street Journal had reported last month.”The vast majority of the suspicious payments were less than $200, and some were as low as $5, the people said, but when added together they totalled millions of dollars,” the report said.Wal-Mart decided to put aside its plans to foray into the Indian market in 2013 by discontinuing its joint venture with Bharti Enterprises Ltd. After that, the company opted to go alone in India.”Wal-Mart was also involved in lobbying before the US Congress in this regard,” the report said, citing Congressional disclosure reports of the past few years.last_img read more

Tags: , , , , , , , , ,

AirAsia has had 1 billion takeover offer for leasing unit Report

first_imgAsia’s largest budget airline AirAsia Bhd (AIRA.KL) has received a $1 billion offer for its aircraft leasing unit, Bloomberg News quoted Chief Executive Tony Fernandes as saying.AirAsia intends to divest the business, Asia Aviation Capital Ltd, at some point, Fernandes told Bloomberg on Monday but added that the offer needs to be discussed further with the board.He was quoted as saying that the business was a “powerful cash generator”.Reuters reported in October that AirAsia has been in talks with lessors, including cash-rich Chinese companies, to sell a stake in its leasing subsidiary.Chinese companies are seeking to grow aggressively in the leasing industry that provides about 40 percent of the planes used by airlines globally.Following the Reuters report, AirAsia said late last year that it had received approaches from investors to co-invest in the leasing unit.last_img read more

Tags: , , , , , , , , ,

Newly elected MPs to be sworn in Thursday

first_imgElection commission secretary Helal Uddin Ahmed talks to newsmen at his office. Photo: UNBThe election commission (EC) on Wednesday sent a letter to the parliament secretary for taking necessary preparations to organise the oath-taking ceremony of the lawmakers elected in the 11th general elections.EC secretary Helal Uddin Ahmed said this while talking to newsmen at Nirbachan Bhaban in the capital on Wednesday.”The gazette containing the details of 298 newly elected MPs has been published and we’ve sent a copy to the parliament secretary so that they can take preparation for the oath-taking ceremony,” he said.He further said, “We heard the oath taking ceremony will be held at 11:00am on Thursday.”Replying to a journalist’s query whether the EC is satisfied with the election, the secretary said, “Our CEC has said that a peaceful election was held in the country and he also thanked everyone related to the election process.”When asked about Oikya Front’s memorandum placed before the EC, he said, “Anyone can place memorandum or letter to the election commission. We accepted it and the commission will take decision about it.””A few incidents of minor violence occurred on the election day and the commission directed the Inspector General of Police to submit a report after investigating the incidents,” he said.The EC secretary also said that the commission has decided to hold the Upazila Election in March as SSC and HSC exams will be held in February and April,” he said.last_img read more

Tags: , , , , , , , , , , ,

15 Afghan Taliban killed in Afghanistan

first_imgSuspected Islamic State militants attacked Taliban fighters attending a funeral in northern Afghanistan on Tuesday and killed at least 15 in the latest violence between the rival groups, officials said.Another five Taliban were wounded in the attack on a house in Sayad district in Sari Pul province, the provincial police chief Abdul Qayum Baqizoi told AFP.A Taliban commander was among the dead, Baqizoi added.The attackers, who were armed with guns and grenades, fled the area.The Sari Pul governor’s spokesman Zabiullah Amani confirmed the death toll.”Daesh and Taliban have been fighting each other for more than two months in (neighbouring) Jowzjan and Sari Pul, killing hundreds on both sides,” Amani said, using the Arabic acronym for the Islamic State group.The Taliban has not commented on the attack. IS did not immediately claim responsibility.IS first emerged in Afghanistan in 2014, overrunning large parts of the eastern provinces of Nangarhar and Kunar near the Pakistan border, where it engaged in a turf war with the Taliban.The group has since expanded north and has been battling the Taliban as well as Afghan and US forces.While the Taliban is Afghanistan’s largest militant group, IS has a small but potent presence in the country and has repeatedly demonstrated an ability to carry out devastating attacks in urban areas, including Kabul.last_img read more

Tags: , , , , , , , , , ,

Is Alcohol A Problem Online Tool Helps Assess Risk And Find Help

first_img Share Kristen Uroda for NPRTreatment for alcohol problems isn’t a one-size-fits-all approach. The NIH has launched a treatment navigator website to connect people to resources and a wide variety of treatment options.The thinking about problem drinking and alcoholism has changed. It’s no longer considered a black-and-white, you have it or you don’t condition.“We now know that there’s a full spectrum in alcohol use disorder,” says George Koob, the director of the National Institute on Alcohol Abuse and Alcohohlism, part of the National Institutes of Health. You can have a mild, moderate or severe problem.And there’s not a one-size-fits-all approach to getting help. There is a wide range of options — from residential “detox” programs to cognitive behavioral therapy, to medications such as naltrexone that can help people drink less, or acamprosate, which can help people stay dry. But many people who might need help don’t know these options exist. It’s a big obstacle to treatment.“A lot of people struggling with alcohol problems do not know where to turn,” Koob says. “Ninety percent of adults in the U.S. with an alcohol use disorder don’t get any treatment whatsoever.”That’s a lot of people, given that an estimated 17 million adults have alcohol use disorder.To help solve this problem, the NIH has launched an online Alcohol Treatment Navigator. It’s a website that helps people explore all the evidence-based options.The site is user-friendly. A list of questions helps determine the best treatment choices. A brief survey helps to determine the range or severity of a problem. The site also connects people to directories of providers. You can type in your ZIP code to find options in your community.For instance, there’s a link to a directory of licensed professional counselors, licensed clinical social workers, clinical psychologists, psychiatrists and other therapists maintained by Psychology Today. There’s also a directory of treatment programs, including residential rehab and outpatient options, which is maintained by the Substance Abuse and Mental Health Services Administration, a federal agency. The NIH does not endorse any providers, it’s simply connecting people to the options. The navigator site also has information about costs and insurance.Research suggests that most people with an alcohol problem can benefit from treatment. According to the NIAAA, about one-third of people who get treatment for an alcohol use disorder are better one year after treatment. “Many others substantially reduce their drinking and report fewer alcohol-related problems,” according to this NIAAA explainer.The new navigator site comes at a time when drinking is on the rise among women, minorities and older adults in the U.S. Dietary guidelines recommend that women should not drink more than one drink per day, and men should not exceed two drinks per day. But a recent study estimates that nearly 32 million adults in the U.S. drink at least occasionally at dangerously high levels.Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Tags: , , , , , , , , , , ,

Chemists deduce the correct structure of the A and B baulamycins

first_img Citation: Chemists deduce the correct structure of the A and B baulamycins (2017, July 27) retrieved 18 August 2019 from https://phys.org/news/2017-07-chemists-deduce-baulamycins.html Journal information: Nature Despite their seemingly simple nature, molecules do not always display their true structure—they actually show a number of unique conformations. This makes it difficult for chemists attempting to understand or recreate them. Especially difficult is getting a handle on the true structure of flexible compounds. In this new effort, the researchers describe their discovery that the structure of A and B baulamycins had been incorrectly described by previous researchers and their efforts to find its correct structure, which led them to develop a new procedure to deduce the structure of a wide variety of natural compounds.A and B baulamycins are polyketide antibiotics with long, flexible carbon chains. Because of their benefits, researchers have tried to create synthetic versions of them, but until now, have failed. The reason appears to be earlier incorrect descriptions of their structure. After making that discovery, the researchers set about determining the true structure.The new method developed by the team involves using both computational methods and nuclear magnetic resonance spectra of the original material to figure out which configurations the compounds naturally take. They then made mixtures of possible isomers of baulamycin A with unequal ratios to identify which of the compounds matched the compound in its natural state. Once they had the correct structure, the team synthesized the compound, which can be used as an antibiotic. The team suggests the same process could be used by other researchers to deduce the correct structure of other natural complex molecules. Previously proposed and actual molecular structures of the baulamycins. Credit: Nature (2017). doi:10.1038/nature23265 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.orgcenter_img Explore further (Phys.org)—A team of chemists at the University of Bristol has correctly deduced the correct structure of the A and B baulamycins. In their paper published in the journal Nature, the team describes how they discovered that the baulamycins had been incorrectly structured and how they developed the new method for deducing the structure of flexible compounds in general. Severin Thompson and Thomas Hoye with the University of Minnesota offer a News & Views piece on the work done by the group in the same issue and explain how the new method could be used to help medical scientists identify natural compounds that might offer medical benefits. Chemists discover structure of cancer drug candidate More information: Synergy of synthesis, computation and NMR reveals correct baulamycin structures, Nature (2017). nature.com/articles/doi:10.1038/nature23265AbstractSmall-molecule, biologically active natural products continue to be our most rewarding source of, and inspiration for, new medicines. Sometimes we happen upon such molecules in minute quantities in unique, difficult-to-reach, and often fleeting environments, perhaps never to be discovered again. In these cases, determining the structure of a molecule—including assigning its relative and absolute configurations—is paramount, enabling one to understand its biological activity. Molecules that comprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task extremely challenging . The baulamycins (A and B) serve as a contemporary example. Isolated in small quantities and shown to have promising antimicrobial activity, the structure of the conformationally flexible molecules was determined largely through J-based configurational analysis, but has been found to be incorrect. Our subsequent campaign to identify the true structures of the baulamycins has revealed a powerful method for the rapid structural elucidation of such molecules. Specifically, the prediction of nuclear magnetic resonance (NMR) parameters through density functional theory—combined with an efficient sequence of boron-based synthetic transformations, which allowed an encoded (labelled) mixture of natural-product diastereomers to be prepared—enabled us rapidly to pinpoint and synthesize the correct structures.last_img read more

Tags: , , , , , , , , , , ,

Genetic study shows explosion of diversity in fish after endCretaceous mass extinction

first_img Reef fish arrived in two waves Journal information: Nature Ecology & Evolution A team of researchers from several institutions across the U.S. has found evidence suggesting that there was an explosion of diversity in fish after the end-Cretaceous mass extinction. In their paper published in the journal Nature Ecology and Evolution, the team describes their genetic study involving more than 1800 species of fish and what they found. Credit: CC0 Public Domain After the end-Cretaceous mass extinction—the one that killed off the dinosaurs—mammals became much more diverse and dominant. Without the dinosaurs to feast on them, they were free to prosper. Much less is known about what went on in the oceans. In this new effort, the researchers have added some new pieces to that puzzle.Prior research has suggested that the asteroid or comet that smashed into the Earth approximately 65 million years ago killed off more than the dinosaurs—approximately 50 percent of all species worldwide disappeared. These include many sharks and other reptiles, leaving a void of sorts in the world’s oceans that allowed fish to flourish. And flourish they did, according to the researchers with this new effort.To learn more about what happened with sea creatures after the end-Cretaceous mass extinction, the researchers collected tissue samples from 118 acanthomorph species, looking specifically at 1,000 DNA sequences that were similar across the genomes of their samples—as part of that effort, they searched for variations in genetic sequences that offered clues regarding how closely related the fish were to one another.The researchers found that six large groups of fish originated over the course of 10 million years after the mass extinction. Of those groups, five were acanthomorphs (spiny-rayed fish). Today, there are approximately 18,000 members of the acanthomorphs species and they represent approximately one in three vertebrate species alive today. That so many of them originated in the time after the dinosaurs disappeared shows that they, like mammals, found the world a much friendlier place—one where they were allowed to prosper. Such an explosion suggests that sharks and other reptile populations and their diversity must have plunged, leaving a vast void for the acanthomorphs to fill. Still unclear is why acanthomorphs, rather than other fish species, became so dominant. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Explore further More information: Michael E. Alfaro et al. Explosive diversification of marine fishes at the Cretaceous–Palaeogene boundary, Nature Ecology & Evolution (2018). DOI: 10.1038/s41559-018-0494-6AbstractThe Cretaceous–Palaeogene (K–Pg) mass extinction is linked to the rapid emergence of ecologically divergent higher taxa (for example, families and orders) across terrestrial vertebrates, but its impact on the diversification of marine vertebrates is less clear. Spiny-rayed fishes (Acanthomorpha) provide an ideal system for exploring the effects of the K–Pg on fish diversification, yet despite decades of morphological and molecular phylogenetic efforts, resolution of both early diverging lineages and enormously diverse subclades remains problematic. Recent multilocus studies have provided the first resolved phylogenetic backbone for acanthomorphs and suggested novel relationships among major lineages. However, these new relationships and associated timescales have not been interrogated using phylogenomic approaches. Here, we use targeted enrichment of >1,000 ultraconserved elements in conjunction with a divergence time analysis to resolve relationships among 120 major acanthomorph lineages and provide a new timescale for acanthomorph radiation. Our results include a well-supported topology that strongly resolves relationships along the acanthomorph backbone and the recovery of several new relationships within six major percomorph subclades. Divergence time analyses also reveal that crown ages for five of these subclades, and for the bulk of the species diversity in the sixth, coincide with the K–Pg boundary, with divergences between anatomically and ecologically distinctive suprafamilial clades concentrated in the first 10 million years of the Cenozoic. © 2018 Phys.org Citation: Genetic study shows explosion of diversity in fish after end-Cretaceous mass extinction (2018, March 13) retrieved 18 August 2019 from https://phys.org/news/2018-03-genetic-explosion-diversity-fish-end-cretaceous.htmllast_img read more

Tags: , , , , , , , , , , ,

Sky in Germany has launched its standalone interne

first_imgSky in Germany has launched its standalone internet TV service, Sky Online, on Android smartphones and tablets.The service, which lets customers pay to access Sky content for a monthly fee with no contract, is now available on Google Nexus 5 phones and Nexus 7 tablets, as well as a range of Samsung Galaxy smartphones and tablets.Similar to Sky’s Now TV service in the UK, Sky Online offers two pay-monthly options – a starter pack and a film pack – plus single-day sports passes to watch all of Sky’s live sports, including Bundesliga football.Julia Schuler, vice president of product development at Sky Germany said that the premium digital service offers customers more flexibility. “With the availability on Android devices we address additional target groups, who want to see our film, series and sports programming while on the move,” she said.At launch, the following Android smartphones and tablets will support Sky Online: Google Nexus 5, Nexus 7, Samsung Galaxy S3, S4, S4 mini, S5, S5 mini, grade 2, grade 3, grade 10.1 and Tab 3 (7.0, 10.1), Table 4 (7.0, 10.1) and Tab S (8.4, 10.5).Sky Online is already available online, on the iPhone, iPad, Xbox One, Samsung Smart TVs and on the Sky Online TV Box.last_img read more

Tags: , , , , , , , , ,